Introduction to Bio Micro Electro
Mechanical Systems
School
of Engineering and Science
Meeting
Time: Friday 3:00pm – 5:30pm
Classroom
Location: C207 (F)
Instructor:
Eui-Hyeok (EH) Yang
Contact
Info: Carnegie 206, eyang@stevens.edu,
201-216-5574
Office
Hours: Friday 1:00pm – 3:00pm
Course
Web Address: None
Prerequisite(s):
ME573 or instructor permission
Corequisite(s):
None
Cross-listed
with: None
COURSE
DESCRIPTION
Bringing together the creative
talents of electrical, mechanical, optical and chemical engineers, and
materials specialists, the science of Bio Micro Electro Mechanical Systems (Bio
MEMS) promises to deliver sensitive, selective, fast, low cost, less invasive,
and more robust methods for diagnostics, individualized treatment, and novel
drug delivery. The goals of this course are to introduce microfabrication,
microfluidics, sensors, actuators, drug delivery systems, micro total analysis
systems and lab-on-a-chip devices, detection and measurement systems and
address the fundamental challenges and limitations involved in designing and
demonstrating BioMEMS devices.
LEARNING
OBJECTIVES
Students will be able to
understand the fundamental challenges and limitations involved in designing and
demonstrating BioMEMS devices.
After successful completion of this
course, students will be able to
·
demonstrate knowledge
of designing, fabricating and characterizing a) microfluidics components and
sensors/actuators, and b) micro total analysis systems and lab-on-a-chip
devices. [SES Outcome 2 Engineering Foundations - the ability to use applied
scientific knowledge (ABET Criterion 3-e)].
FORMAT
AND STRUCTURE
·
This course is comprised of weekly
lectures with extensive hands-on course projects embedded in the lectures.
COURSE
MATERIALS
Textbook(s): Introduction to BioMEMS by
Albert Folch
(ISBN 978-1-4398-1839-8), CRC Press, 2013
Other Readings:
We will use a
combination of selections from references books, MEMS journal publications and
on-line information.
References
Books: Fundamentals of
BioMEMS and Medical Microdevices by Steven Saliterman (ISBN 081945977-1)
COURSE
REQUIREMENTS
Attendance All
students start the semester 10 points for attendance. A student will lose 1
points for each additional absences. Excused absences (religious or medical,
noted in via email to the professor prior to the absence occurring) accompanied
by proper documentation will not lead to point deductions.
Case Study Each
student is expected to make a presentation on a selected topic on BioMEMS by
(a) identifying the relevant research literature representing the state of the
art on a specific research subject, (b) structuring, summarizing and critiquing
this body of literature, and (c) drawing conclusions from and evaluating the
significance and impact of this body of literature.
Term Project Students will experience
hands-on projects including the device design, mask design, process design
(fabrication), or modeling, and characterization.
Quiz Several quizzes
will be given during the class.
GRADING
PROCEDURES
·
There are 10 possible points that a student can
earn in this course. The final grade will be based on the number of points
earned out of the number of points possible. Percentages are also listed below.
ACADEMIC
INTEGRITY
Undergraduate Honor System
Enrollment
into the undergraduate class of Stevens Institute of Technology signifies a
student's commitment to the Honor System. Accordingly, the provisions of the
Stevens Honor System apply to all undergraduate students in coursework and
Honor Board proceedings. It is the responsibility of each student to become
acquainted with and to uphold the ideals set forth in the Honor
System Constitution. More information about the Honor System
including the constitution, bylaws, investigative procedures, and the penalty
matrix can be found online at http://web.stevens.edu/honor/
The
following pledge shall be written in full and signed by every student on all
submitted work (including, but not limited to, homework, projects, lab reports,
code, quizzes and exams) that is assigned by the course instructor. No work
shall be graded unless the pledge is written in full and signed.
“I pledge my honor that I have abided by the
Stevens Honor System.”
Reporting
Honor System Violations
Students
who believe a violation of the Honor System has been committed should report it
within ten business days of the suspected violation. Students have the option
to remain anonymous and can report violations online at www.stevens.edu/honor.
Graduate Student Code of Academic
Integrity
All
Stevens graduate students promise to be fully truthful
and avoid dishonesty, fraud, misrepresentation, and deceit of any type in
relation to their academic work. A student’s submission of work for academic
credit indicates that the work is the student's own. All outside assistance
must be acknowledged. Any student who violates this code or who knowingly
assists another student in violating this code shall be subject to discipline.
All
graduate students are bound to the Graduate Student Code of Academic Integrity
by enrollment in graduate coursework at Stevens. It is the responsibility of
each graduate student to understand and adhere to the Graduate Student Code of
Academic Integrity. More information including types of violations, the process
for handling perceived violations, and types of sanctions can be found at www.stevens.edu/provost/graduate-academics.
Special Provisions for Undergraduate
Students in 500-level Courses
The
general provisions of the Stevens Honor System do not apply fully to graduate
courses, 500 level or otherwise. Any student who wishes to report an
undergraduate for a violation in a 500-level course shall submit the report to
the Honor Board following the protocol for undergraduate courses, and an investigation
will be conducted following the same process for an appeal on false accusation
described in Section 8.04 of the Bylaws of the Honor System. Any student who
wishes to report a graduate student may submit the report to the Dean of
Graduate Academics or to the Honor Board, who will refer the report to the
Dean. The Honor Board Chairman will give the Dean of Graduate Academics weekly
updates on the progress of any casework relating to 500-level courses. For more
information about the scope, penalties, and procedures pertaining to
undergraduate students in 500-level courses, see Section 9 of the Bylaws of
the Honor System document, located on the Honor Board website.
EXAM
ROOM CONDITIONS
The
following procedures apply to quizzes and exams for this course. As the
instructor, I reserve the right to modify any conditions set forth below by
printing revised Exam Room Conditions on the quiz or exam.
1.
Students may use the following devices
during quizzes and exams. Any electronic devices that are not mentioned in the
list below are not permitted.
Device |
Permitted? |
|
Yes |
No |
|
Laptops |
|
x |
Cell Phones |
|
x |
Tablets |
|
x |
Smart Watches |
|
x |
Google Glass |
|
x |
Other (Nonprogrammable
calculator) |
|
x |
2.
Students may use the following materials
during quizzes and exams. Any materials that are not mentioned in the list
below are not permitted.
Material |
Permitted? |
|
Yes |
No |
|
Handwritten Notes |
|
x |
Typed Notes Conditions: one
8x10 sheet (Times 11 and black) is permitted. |
|
x |
Textbooks |
x |
x |
Readings |
|
x |
3.
Students are not allowed to work
with or talk to other students during quizzes and/or exams.
LEARNING
ACCOMODATIONS
Stevens Institute of Technology is dedicated to
providing appropriate accommodations to students with documented disabilities.
Student Counseling and Disability Services works with undergraduate and
graduate students with learning disabilities, attention deficit-hyperactivity
disorders, physical disabilities, sensory impairments, and psychiatric
disorders in order to help students achieve their academic and personal
potential. They facilitate equal access to the educational programs and
opportunities offered at Stevens and coordinate reasonable accommodations for
eligible students. These services are designed to encourage independence and
self-advocacy with support from SCDS staff. The SCDS staff
will facilitate the provision of accommodations on a case-by-case basis. These
academic accommodations are provided at no cost to the student.
Disability Services
Confidentiality Policy
Student Disability
Files are kept separate from academic files and are stored in a secure location
within the office of Student Counseling, Psychological & Disability
Services. The Family Educational Rights Privacy Act (FERPA, 20 U.S.C. 1232g;
34CFR, Part 99) regulates disclosure of disability documentation and records
maintained by Stevens Disability Services. According to this act, prior written
consent by the student is required before our Disability Services office may
release disability documentation or records to anyone. An exception is made in
unusual circumstances, such as the case of health and safety emergencies.
For more information about Disability Services
and the process to receive accommodations, visit https://www.stevens.edu/sit/counseling/disability-services. If you have any questions
please contact:
Lauren
Poleyeff, Psy.M., LCSW - Diability Services Coordinator and Staff Clinician in Student
Counseling and Disability Services at Stevens Institute of Technology at lpoleyef@stevens.edu or by phone (201) 216-8728.
INCLUSIVITY
STATEMENT
Stevens
Institute of Technology believes that diversity and inclusiveness are essential
to excellence in education and innovation. Our community represents a rich
variety of backgrounds, experiences, demographics and perspectives and Stevens
is committed to fostering a learning environment where every individual is
respected and engaged. To facilitate a dynamic and inclusive educational
experience, we ask all members of the community to:
·
be open to the perspectives of others
·
appreciate the uniqueness their
colleagues
·
take advantage of the opportunity to learn
from each other
·
exchange experiences, values and beliefs
·
communicate in a respectful manner
·
be aware of individuals who are
marginalized and involve them
·
keep confidential discussions private
TENTATIVE
COURSE SCHEDULE
The following is a tentative course schedule. Any and
all changes to this schedule will be communicated to you 1) in class and 2) via
email.
Week Starting |
Topic(s) |
Readings |
Assignment/Quiz |
1 |
Intro to
Bio MEMS |
§
Course introduction §
BioMEMS definition |
Student Introduction due in class
|
2 |
Microfabrication
I |
§
Why bother making things small? §
Photolithography |
Case study assignment Lithography Demo |
3 |
Microfabrication
II |
§
Etching §
Thin Film |
Term-Project assignment PVD Demo |
4 |
Soft
Microfabrication |
§
Soft lithography |
ICP etcher Demo |
5 |
Micropatterning of Cells |
§
Surface engineering §
Micropatterns of
SAMs §
Micropatterns of
cells |
Case
study: 1,2 |
6 |
Presentation (Proposal), Quiz |
PDMS Demo |
|
7 |
Microfluidics
I |
§
Why go small? §
Microscale behavior of fluidics §
Fluids in electrical fields |
Case
study: 3,4 |
8 |
Microfluidics
II |
§
Microfluidics channels §
Droplet microfluidics |
Case study: 5,6 |
9 |
Microfluidics
III |
§
Active flow control |
Case study: 7,8 |
10) |
Separation and
Detection of Molecules on a Chip |
§
Point-of-care diagnostics §
Chips for genomics |
Case study: 9,10 |
11 |
Presentation (Progress), Quiz |
||
12 |
Cell
Sorting and Handling |
§
Cell sorting/trapping §
Cell culture |
Case study: 11,12 |
13 |
Cell
Biology on Micropatterns and Implantable Devices |
§ Cellular microenvironment § Topographical guidance § Microelectrodes § Lenses and needles |
Case study: 13,14 |
14 |
Poster (Final) Presentation, Project (Final)
Report due |