Course Title: Introduction to Bio Micro Electro Mechanical Systems (BioMEMS)                                               

Course #: ME 581

Catalog Description:  Bringing together the creative talents of electrical, mechanical, optical and chemical engineers, and materials specialists, the science of Bio Micro Electro Mechanical Systems (Bio MEMS) promises to deliver sensitive, selective, fast, low cost, less invasive, and more robust methods for diagnostics, individualized treatment, and novel drug delivery. The goals of this course are to introduce microfabrication, microfluidics, sensors, actuators, drug delivery systems, micro total analysis systems and lab-on-a-chip devices, detection and measurement systems and address the fundamental challenges and limitations involved in designing and demonstrating BioMEMS devices.                                

Cross-listing: NANO

Percentages for:  Case study 30%, Project 40% (proposal, progress report, poster), Quiz 30%

For Graduate Credit toward Degree or Certificate         Yes                                                           

Course’s Objective:  Students will be able to demonstrate knowledge of designing, fabricating and characterizing a) microfluidics, sensors/actuators, drug delivery systems, b) micro total analysis systems and lab-on-a-chip devices, and c) detection and measurement systems.

Textbook(s) or References: Introduction to BioMEMS by Albert Folch (ISBN 978-1-4398-1839-8), CRC Press, 2013

 

In addition, we will use a combination of selections from references books, MEMS journal publications and on-line information.

 

References Books: Fundamentals of BioMEMS and Medical Microdevices by Steven Saliterman   (ISBN 081945977-1)

 

Mode of Delivery             Class                

Program/Department Ownership: Mechanical Engineering

Syllabus:

Week

Topic(s)

Description

Reading

Case Study

1

Intro to Bio MEMS

§  Course introduction

§  BioMEMS definition

 

 

2

Silicon Microfabrication I

§  Photolithography

§  Micromachining

§   

CH1

 

3

Silicon Microfabrication II

§  Soft lithography

§  Nanofabrication techniques

§  Fabrication based on self-assembly

CH1

·   Case study assignment

 

4

Micropatterning of Substrates and Cells

§  Surface engineering

§  Micropatterns of self-assembled monolayers (SAMs)

§  Micropatterns of cells

CH1, CH2

·  Term-Project assignment

5

Proposal presentation

 

 

 

6

Microfluidics I

§  Why go small?

§  Microscale behavior of fluidics

§  Fluids in electrical fields

§  Fabrication of microfluidic channels

§  Operation of microfluidics channels

CH3

Case study: 1

7

Microfluidics II

§  Droplet microfluidics

§  Active flow control

§  Micromixers

CH3

Case study: 2

8

Molecular Biology on a Chip

§  Point-of-care diagnostics

§  Problems with microfluidic sample preparation

§  Chips for genomics and proteomics

CH4

Case study: 4

·    

9

Sensor Principles and  Microsensors

§  Definitions

§  Biochemical analysis using force sensors

CH4

Case study: 3

·  Progress report

·  Presentations

10

Cell-Based Chips for Biotechnology

§  Cell sorting

§  Cell trapping

§  Microfluidic cell culture laboratories

CH5

Case study: 5

11

BioMEMS for Cell Biology

§  An enabling technology

§  Cell-substrate signaling

§  Cell-cell communication

§  Cell migration

§  BioMEMS for cellular neurobiology

CH6

Case study: 6

12

Tissue Engineering

§  Microscaffording

§  Micropatterned cocultures

§  Stem cell engineering

CH7

Case study: 7

13

Implantable Microdevices

§  Implantable Microelectrodes

§  Microtools for Surgery

CH8

 

13

Quiz

 

 

 

14

Presentation Sessions

·   Poster Presentations

 

 

 

Point of Contact: Prof. Eui-Hyeok Yang

Prof. E. H. Yang, Stevens Institute of Technology , 스티븐스 공대, 양의혁 교수

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